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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2019; 7(15): 1978-1985
Published online Aug 6, 2019. doi: 10.12998/wjcc.v7.i15.1978
Published online Aug 6, 2019. doi: 10.12998/wjcc.v7.i15.1978
Changes in corneal endothelial cell density in patients with primary open-angle glaucoma
Zi-Yan Yu, Bo Qu, Department of Ophthalmology, 4th Affiliated Hospital of China Medical University, Eye hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang 110005, Liaoning Province, China
Ling Wu, Department of Ophthalmology, the 4th people’s Hospital of Shenyang, Shenyang 110005, Liaoning Province, China
Author contributions: All authors helped to perform the research; Qu B drafted the manuscript; Yu ZY and Wu L reviewed the published articles and analyzed the data; All authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the 4th Affiliated Hospital of China Medical University, No. EC-2019-KS-018.
Informed consent statement: Written informed consent was obtained from all of the patients.
Conflict-of-interest statement: The authors have stated that they have no conflicts of interest.
Data sharing statement: The datasets of this study are readily available from the corresponding author upon reasonable request.
STROBE statement: The guidelines of the STROBE statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bo Qu, MD, PhD, Associate Professor, Dr., Department of Ophthalmology, 4th affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang 110005, Liaoning Province, China. dolphinemu@foxmail.com
Telephone: +86-130-66660193 Fax: +86-024-62037227
Received: April 9, 2019
Peer-review started: April 12, 2019
First decision: May 31, 2019
Revised: June 28, 2019
Accepted: July 3, 2019
Article in press: July 4, 2019
Published online: August 6, 2019
Processing time: 119 Days and 23.6 Hours
Peer-review started: April 12, 2019
First decision: May 31, 2019
Revised: June 28, 2019
Accepted: July 3, 2019
Article in press: July 4, 2019
Published online: August 6, 2019
Processing time: 119 Days and 23.6 Hours
Core Tip
Core tip: Loss of corneal endothelial cells have been reported in primary open-angle glaucoma (POAG) patients. Elevated intraocular pressure, cell toxicity after long-term exposure to preservatives and glaucoma surgery have been reported to be possible mechanisms for endothelial damage. In this study, we aimed to document the corneal endothelial changes and their correlations with mean intraocular pressure between POAG patients and normal controls. We found that the corneal endothelial cell density in POAG patients is decreased and the average endothelial cell area is increased compared with those in healthy controls. High intraocular pressure and anti-glaucoma medication in POAG may be the main causes of corneal endothelial cell damage.