Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2019; 7(14): 1837-1843
Published online Jul 26, 2019. doi: 10.12998/wjcc.v7.i14.1837
Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report
Simona Gurzu, Constantin Copotoiu, Alexandra Tugui, Cedric Kwizera, Rita Szodorai, Ioan Jung
Simona Gurzu, Alexandra Tugui, Rita Szodorai, Ioan Jung, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, Targu Mures 530149, Romania
Simona Gurzu, Research Center (CCAMF), University of Medicine, Pharmacy, Sciences and Technology, Targu Mures 540139, Romania
Constantin Copotoiu, Cedric Kwizera, Department of Surgery, University of Medicine, Pharmacy, Sciences and Technology, Targu Mures 530149, Romania
Author contributions: Gurzu S drafted the article and diagnosed the case; Copotoiu C performed the surgical interventions; Alexandra Tugui contributed to the histological diagnosis and searched literature data; Kwizera C contributed to the surgical intervention and managed clinical data; Szodorai R searched archived data; Jung I contributed to the diagnosis and immunohistochemical assessment and confer the final agreement for publication; Gurzu S and Kwizera C had equally contribution to the paper.
Supported by a grant of the Romanian National Authority for Scientific Research, CNCS – UEFISCDI, No. 20 PCCF/2018, code: PN-III-P4-ID-PCCF-2016-0006.
Informed consent statement: Signed consent of patient was obtained.
Conflict-of-interest statement: The authors deny any conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Simona Gurzu, MD, PhD, Chief Doctor, Full Professor, Consulting Pathologist, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, Targu Mures 530149, Romania. simona.gurzu@umftgm.ro
Telephone: +40-745-673550Fax: +40-265-210407
Received: February 26, 2019
Peer-review started: February 26, 2019
First decision: April 18, 2019
Revised: May 28, 2019
Accepted: June 10, 2019
Article in press: June 10, 2019
Published online: July 26, 2019
Processing time: 150 Days and 18.6 Hours
Core Tip

Core tip: In this paper we presented an extremely rare histological variant of aggressive gastric carcinomas. Few than 60 cases of primary choriocarcinoma of the stomach were published in English literature. The complex immunoprofile of tumor cells, correlated with literature data, showed that gastric mucosa cells can present a multilineage differentiation and choriocarcinoma is a primary microsatellite stable adenocarcinoma without germ cell origins.