Systematic Reviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2019; 7(14): 1825-1836
Published online Jul 26, 2019. doi: 10.12998/wjcc.v7.i14.1825
Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review
Christoph Kolja Boese, Philipp Lechler, Michael Frink, Michael Hackl, Peer Eysel, Christian Ries
Christoph Kolja Boese, Michael Hackl, Peer Eysel, Christian Ries, Department of Orthopaedic and Trauma Surgery, University Hospital of Cologne, Cologne 50931, Germany
Philipp Lechler, Clinic for Trauma and Hand Surgery, Kreiskliniken, Altötting 84503, Germany
Philipp Lechler, Michael Frink, Center for Orthopaedics and Trauma Surgery, University Hospital Giessen and Marburg, Marburg 35043, Germany
Author contributions: Boese CK designed the study and performed the literature analysis; Boese CK analysed the data and Ries C reviewed the data analysis critically; Boese CK and Ries C wrote substantial parts of the manuscript; Lechler P and Frink M provided input to the study concept; Lechler P, Frink M, Hackl M and Eysel P critically reviewed the manuscript and provided expert opinion.
Conflict-of-interest statement: Boese CK is employee of Smith and Nephew GmbH, Germany. The other authors report no conflict of interest. All authors have no financial disclosures with respect to this manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Christoph Kolja Boese, MD, Senior Lecturer, Department of Orthopaedic and Trauma Surgery, University Hospital of Cologne, Joseph-Stelzmann Street 9, Cologne 50931, Germany. christoph.boese@uk-koeln.de
Telephone: +49-221-4784682 Fax: +49-221-47886731
Received: March 8, 2019
Peer-review started: March 11, 2019
First decision: May 10, 2019
Revised: May 28, 2019
Accepted: June 27, 2019
Article in press: June 27, 2019
Published online: July 26, 2019
Processing time: 141 Days and 0.8 Hours
Core Tip

Core tip: Periprosthetic joint infection of total joint replacement poses a significant socio-economic burden. One factor is the need for prolonged parenteral antibiotic therapy. Outpatient parenteral antibiotic therapy (OPAT) might reduce costs compared to inpatient (IPAT) settings. A systematic literature review was performed to compare economic impact of OPAT and IPAT. Twenty-one articles were identified of which 20 reported economic benefits of OPAT. While the heterogeneity of studies limited the interpretation and generalization, overall beneficial cost effects of OPAT were shown. Future studies should focus on specific economic outcomes of OPAT for PPJI.