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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2018; 6(9): 259-273
Published online Sep 6, 2018. doi: 10.12998/wjcc.v6.i9.259
Published online Sep 6, 2018. doi: 10.12998/wjcc.v6.i9.259
Conversion therapy and suitable timing for subsequent salvage surgery for initially unresectable hepatocellular carcinoma: What is new?
Ze-Feng Zhang, Yu-Jun Luo, Quan Lu, Shi-Xue Dai, Wei-Hong Sha, Department of Gastroenterology and Hepatology, Guangdong Geriatrics Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Author contributions: Zhang ZF and Luo YJ drew up the manuscript; Lu Q and Dai SX performed the literature search and data extraction; Sha WH revised the manuscript.
Conflict-of-interest statement: All the authors declare that they have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei-Hong Sha, MD, PhD, Professor, Chief, Department of Gastroenterology and Hepatology, Guangdong Geriatrics Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Second Road, Guangzhou 510080, Guangdong Province, China. syshaweihong@scut.edu.cn
Telephone: +86-20-83827812-61911 Fax: +86-20-83827812-61922
Received: March 29, 2018
Peer-review started: March 30, 2018
First decision: April 26, 2018
Revised: July 18, 2018
Accepted: August 6, 2018
Article in press: August 7, 2018
Published online: September 6, 2018
Peer-review started: March 30, 2018
First decision: April 26, 2018
Revised: July 18, 2018
Accepted: August 6, 2018
Article in press: August 7, 2018
Published online: September 6, 2018
Core Tip
Core tip: Since the treatment for initially unresectable hepatocellular carcinoma (HCC) patients is still controversial, we emphasize the importance and effectiveness of different conversion therapies and subsequent salvage surgery. We also introduce the common conversion therapies including their indications, advantages and shortcomings. Challengingly we try to elaborate on the suitable subsequent salvage surgery timing. We advocate the reasonable unified application of these to have the full effect of complementary advantages, to promote their therapeutic effect, and to increase the survival rate of the initially unresectable HCC patients.