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World J Clin Cases. Sep 6, 2018; 6(9): 233-241
Published online Sep 6, 2018. doi: 10.12998/wjcc.v6.i9.233
Hepatitis B virus-persistent infection and innate immunity defect: Cell-related or virus-related?
Jian Tang, Zhen-Yu Wu, Rong-Juan Dai, Jing Ma, Guo-Zhong Gong
Jian Tang, Zhen-Yu Wu, Jing Ma, Guo-Zhong Gong, Department of Infectious Disease, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Rong-Juan Dai, Department of Infectious Disease, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Tang J, Wu ZY and Gong GZ wrote the manuscript; Dai RJ and Ma J performed critical revision and editing of the manuscript; all authors gave approval of the final version.
Supported by Natural Science Foundation of China, No. 81500455.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guo-Zhong Gong, PhD, Professor, Department of Infectious Disease, the Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. gongguozhong@csu.edu.cn
Telephone: +86-731-85292105 Fax: +86-731-85292173
Received: April 3, 2018
Peer-review started: April 3, 2018
First decision: May 29, 2018
Revised: July 31, 2018
Accepted: August 6, 2018
Article in press: August 7, 2018
Published online: September 6, 2018
Processing time: 157 Days and 15.3 Hours
Core Tip

Core tip: This review covers the following core concepts of hepatitis B virus (HBV) persistence, according to the most up-to-date literature: Hepatocytes lack immune responsiveness to HBV; Innate immune cells display weak responses at the early stages of HBV infection; HBV impairs functions of innate immune cells and select signaling pathways to evade immune recognition and response.