Prospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2018; 6(15): 952-960
Published online Dec 6, 2018. doi: 10.12998/wjcc.v6.i15.952
Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission
Ryosuke Takano, Satoshi Osawa, Takahiro Uotani, Shinya Tani, Natsuki Ishida, Satoshi Tamura, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Takahisa Furuta, Hiroaki Miyajima, Ken Sugimoto
Ryosuke Takano, Takahiro Uotani, Natsuki Ishida, Satoshi Tamura, Mihoko Yamade, Yasushi Hamaya, Hiroaki Miyajima, Ken Sugimoto, First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Satoshi Osawa, Shinya Tani, Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Moriya Iwaizumi, Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Takahisa Furuta, Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Author contributions: Takano R and Osawa S contributed to the study concept and design, analysis and interpretation of data and draughting of the manuscript; Uotani T, Tani S, Ishida N, Tamura S and Hamaya Y contributed to patient management, acquisition of data of CCE-2; Yamade M and Iwaizumi M contributed to analysis and interpretation of data; Furuta T and Miyajima H were involved in study supervision; Sugimoto K and Osawa S critically revised the manuscript for important intellectual content; All authors approved the final manuscript version prior to submission.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Hamamatsu University School of Medicine.
Clinical trial registration statement: This study is registered at UMIN clinical trial register system. The registration number is UMIN000030539.
Informed consent statement: Written informed consent for participation in the study was obtained from all patients.
Conflict-of-interest statement: The authors declare no conflicts of interest associated with this manuscript.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Satoshi Osawa, MD, PhD, Assistant Professor, Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan. sososawa@hama-med.ac.jp
Telephone: +81-53-4352261 Fax: +81-53-4349447
Received: August 24, 2018
Peer-review started: August 24, 2018
First decision: October 11, 2018
Revised: October 28, 2018
Accepted: November 7, 2018
Article in press: November 7, 2018
Published online: December 6, 2018
Processing time: 105 Days and 0.4 Hours
Core Tip

Core tip: Although mucosal healing is a newly established therapeutic goal in ulcerative colitis (UC), it remains unclear whether evaluating endoscopic activity using colon capsule endoscopy (CCE-2) is able to predict outcome. The present study was a prospective study to evaluate the usefulness of CCE-2 in patients with UC, especially in clinical remission. We revealed that our reduced-volume preparation regimen for CCE-2 could attain a high rate of total colon observation and high acceptability, and that assessment of endoscopic activity by CCE-2 using Mayo endoscopic subscore and Ulcerative Colitis Endoscopic Index of Severity can predict outcome.