Xue J, Wang XM, Li Y, Zhu L, Liu XM, Chen J, Chi SH. Highlighting the importance of early diagnosis in progressive multi-organ involvement of IgG4-related disease: A case report and review of literature. World J Clin Cases 2018; 6(13): 707-715 [PMID: 30430130 DOI: 10.12998/wjcc.v6.i13.707]
Corresponding Author of This Article
Shu-Hong Chi, MD, MSc, Associate Professor, Chief Doctor, Department of Rheumatology, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. chi794613@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2018; 6(13): 707-715 Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.707
Highlighting the importance of early diagnosis in progressive multi-organ involvement of IgG4-related disease: A case report and review of literature
Jing Xue, Xue-Mei Wang, Yan Li, Li Zhu, Xiao-Ming Liu, Juan Chen, Shu-Hong Chi
Jing Xue, Xue-Mei Wang, Shu-Hong Chi, Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Jing Xue, Xiao-Ming Liu, Institute of Human Stem Cell Research, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Yan Li, Li Zhu, Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Juan Chen, Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Author contributions: Xue J collected patient’s clinical data, made a review of the literature and drafted the manuscript; Wang XM, Zhu L, Li Y and Chen J contributed to the acquisition, analysis and interpretation of histopathological findings; Liu XM revised the manuscript and Chi SH participated in collecting patient’s clinical data and critically revised the manuscript for intellectual contents; all authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shu-Hong Chi, MD, MSc, Associate Professor, Chief Doctor, Department of Rheumatology, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. chi794613@163.com
Telephone: +86-951-6744457
Received: July 31, 2018 Peer-review started: July 31, 2018 First decision: August 24, 2018 Revised: September 16, 2018 Accepted: October 11, 2018 Article in press: October 11, 2018 Published online: November 6, 2018 Processing time: 98 Days and 6.1 Hours
Core Tip
Core tip: IgG4-related disease (IgG4-RD) is an easily misdiagnosed immune disorder with an elevated serum IgG4 and multiple organ involvements. Hence, it is important in early diagnosis for guiding clinical treatments. Here, we report an interesting case of a woman with progressive multi-organ involvement of IgG4-RD for 19 years. The 67-year-old woman has suffered from progressive diseases of multiple organs, including lacrimal glands, kidneys, parotid glands, submandibular glands, salivary glands, pituitary, pancreas and lung. Patients with IgG4-RD normally respond well to steroid therapy; however, the broad spectrum of manifestation with commonly clinical features of other diseases easily leads to misdiagnosis and improper treatment in clinical settings. Therefore, this report highlights the importance of early diagnosis in this autoimmune disease.
