Case Report
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2018; 6(13): 671-674
Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.671
Incident hepatocellular carcinoma developing during tenofovir alafenamide treatment as a rescue therapy for multi-drug resistant hepatitis B virus infection: A case report and review of the literature
Jian-Chun Lu, Long-Gen Liu, Lin Lin, Shu-Qin Zheng, Yuan Xue
Jian-Chun Lu, Long-Gen Liu, Shu-Qin Zheng, Yuan Xue, Department of Liver Diseases, the Third People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
Jian-Chun Lu, Long-Gen Liu, Lin Lin, Shu-Qin Zheng, Yuan Xue, Institute of Hepatology, the Third People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
Lin Lin, Department of Pharmacy, the Third People’s Hospital of Changzhou, Changzhou 213000, Jiangsu Province, China
Author contributions: Xue Y designed the research; Lu JC, Liu LG, Lin L and Zheng SQ collected and confirmed the data; Lu JC wrote the manuscript; Xue Y revised the manuscript.
Supported by the Chinese Foundation for Hepatitis Prevention and Control- WBE Liver Fibrosis Foundation, No. WBE20161013; and the Science and Technology project of Changzhou, No. CJ20160024 and No. CJ20179030.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yuan Xue, PhD, Chief Doctor, Department of Liver Diseases, the Third People’s Hospital of Changzhou, No. 300, Lanling North Road, Changzhou 213000, Jiangsu Province, China. xueyuan80908@163.com
Telephone: +86-519-82008326 Fax: +86-519-82009010
Received: July 24, 2018
Peer-review started: July 24, 2018
First decision: August 30, 2018
Revised: September 5, 2018
Accepted: October 12, 2018
Article in press: October 12, 2018
Published online: November 6, 2018
Processing time: 105 Days and 22.3 Hours
Core Tip

Core tip: Tenofovir alafenamide rescues multidrug resistance and renal dysfunction in an old patient but does not eliminate the risk of hepatocellular carcinoma (HCC) development. Despite controlling the viral load, risk of HCC exists and should be monitored in cirrhotic patients.