Chen B, Xiong L, Chen WD, Zhao XH, He J, Zheng YW, Kong FH, Liu X, Zhang ZJ, Miao XY. Photodynamic therapy for middle-advanced stage upper gastrointestinal carcinomas: A systematic review and meta-analysis. World J Clin Cases 2018; 6(13): 650-658 [PMID: 30430120 DOI: 10.12998/wjcc.v6.i13.650]
Corresponding Author of This Article
Xiong-Ying Miao, MD, Professor, Department of General Surgery, The Second Xiangya Hospital, Central South University, No. 139, Middle Renmin Road, Changsha 410011, Hunan Province, China. miaoxiongying3016@csu.edu.cn
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2018; 6(13): 650-658 Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.650
Photodynamic therapy for middle-advanced stage upper gastrointestinal carcinomas: A systematic review and meta-analysis
Bo Chen, Li Xiong, Wei-Dong Chen, Xiao-Hua Zhao, Jun He, Yan-Wen Zheng, Fan-Hua Kong, Xi Liu, Zi-Jian Zhang, Xiong-Ying Miao
Bo Chen, Li Xiong, Wei-Dong Chen, Xiao-Hua Zhao, Jun He, Yan-Wen Zheng, Fan-Hua Kong, Xi Liu, Zi-Jian Zhang, Xiong-Ying Miao, Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Miao XY and Xiong L designed the research; Chen B, Chen WD and Zhao XH contribute equally to this work; He J and Zheng YW contributed to analytic tools; Kong FH and Liu X analyzed the data; Chen B and Zhang ZJ wrote the paper; Chen B and Xiong L participated in revisions of the manuscript.
Supported bythe National Natural Science Foundation of China, No. 81372628, No. 81773293, and No.31660266; the Natural Science Foundation of Hunan Province, No. 12JJ5048; and the Science and Technology Plan Fund of Hunan Province, P.R. China, No. 2018JJ3758, No. 2017WK2063, No. 2017DK2011, No. 2015GK3117, and No. 2014WK2016.
PRISMA 2009 Checklist statement: The manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiong-Ying Miao, MD, Professor, Department of General Surgery, The Second Xiangya Hospital, Central South University, No. 139, Middle Renmin Road, Changsha 410011, Hunan Province, China. miaoxiongying3016@csu.edu.cn
Telephone: +86-731-88836045 Fax: +86-731-84895199
Received: July 19, 2018 Peer-review started: July 19, 2018 First decision: August 25, 2018 Revised: September 13, 2018 Accepted: October 11, 2018 Article in press: October 11, 2018 Published online: November 6, 2018 Processing time: 110 Days and 2.4 Hours
Core Tip
Core tip: Photodynamic therapy (PDT) is minimally invasive compared with chemotherapy and radiotherapy for the treatment of cancers. Limited data exist regarding the efficacy of PDT alone or combined with radiotherapy and chemotherapy for the treatment of middle-advanced stage upper gastrointestinal carcinomas. Therefore, we performed a systematic review and meta-analysis of ten available randomized controlled clinical trials that addressed the efficacy of PDT alone or combined with radiotherapy and chemotherapy in patients with middle-advanced stage upper gastrointestinal carcinomas. Our analysis showed that PDT may be suitable for single or combined treatment of middle-advanced stage upper gastrointestinal carcinomas, especially for elderly patients, those with severe diseases, those with severe complications, and those unwilling to undergo surgery.
