Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2018; 6(12): 521-530
Published online Oct 26, 2018. doi: 10.12998/wjcc.v6.i12.521
Declining diagnostic accuracy of non-invasive fibrosis tests is associated with elevated alanine aminotransferase in chronic hepatitis B
Lin Wang, Yao-Xin Fan, Xiao-Guang Dou
Lin Wang, Yao-Xin Fan, Xiao-Guang Dou, Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China
Author contributions: Wang L and Fan YX designed the study, enrolled the patients, analyzed the data and prepared the manuscript; Dou XG designed and supervised the study.
Supported by the Liaoning Provincial Science and Technology Key Project for Translational Medicine, No. 2014225020; Outstanding Scientific Fund of Shengjing Hospital, No. 201102; Liaoning Provincial Science and Technology Key Project for Translational Medicine, No. 2016509; and National Science and Technology Major Project, Nos. 2017ZX10201201, 2017ZX10202202, 2017ZX10202203.
Institutional review board statement: The study was approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University.
Informed consent statement: Patients were not required to provide informed consent for the study because the analysis used anonymous clinical data obtained after each patient provided written consent for treatment.
Conflict-of-interest statement: All authors declare no conflict of interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiao-Guang Dou, MD, Professor, Department of Infectious Diseases, Shengjing Hospital of China Medical University, No. 39, Huaxiang Road, Shenyang 110022, Liaoning Province, China. guang40@163.com
Telephone: +86-24-9661562211
Received: July 19, 2018
Peer-review started: July 19, 2018
First decision: August 8, 2018
Revised: August 17, 2018
Accepted: October 9, 2018
Article in press: October 9, 2018
Published online: October 26, 2018
Processing time: 99 Days and 23.2 Hours
Core Tip

Core tip: Because of their high applicability and good interlaboratory reproducibility, many convenient non-invasive fibrosis tests have been established. To explore the effect of alanine aminotransferase (ALT) on the performance of non-invasive fibrosis tests in chronic hepatitis B (CHB) patients, we retrospectively analyzed 599 treatment-naive and biopsy-proven CHB patients at our hospital. The diagnostic accuracy of the non-invasive tests decreased in a stepwise manner with the increase in ALT. ALT has a significant effect on the diagnostic performance of non-invasive fibrosis tests.