Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2016; 4(2): 38-48
Published online Feb 16, 2016. doi: 10.12998/wjcc.v4.i2.38
Cytopathologic diagnosis of fine needle aspiration biopsies of thyroid nodules
Evangelos P Misiakos, Niki Margari, Christos Meristoudis, Nickolas Machairas, Dimitrios Schizas, Konstantinos Petropoulos, Aris Spathis, Petros Karakitsos, Anastasios Machairas
Evangelos P Misiakos, Dimitrios Schizas, Konstantinos Petropoulos, Anastasios Machairas, 3rd Department of Surgery, Attikon University Hospital, University of Athens School of Medicine, Attica, 12462 Athens, Greece
Niki Margari, Christos Meristoudis, Aris Spathis, Petros Karakitsos, Department of Cytopathology, Attikon University Hospital, University of Athens School of Medicine, Attica, 12462 Athens, Greece
Nickolas Machairas, 2nd Department of Propedeutic Surgery, Laiko Hospital, University of Athens School of Medicine, Attica, 11527 Athens, Greece
Author contributions: Misiakos EP, Margari N, Meristoudis C, Petropoulos K, and Spathis A contributed significantly in preparation, collection of data, writing and critically revising the manuscript; Machairas N, Schizas D, Karakitsos P and Machairas A contributed in data analysis, and writing the manuscript.
Conflict-of-interest statement: There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Evangelos P Misiakos, MD, FACS, Associate Professor of Surgery, Attikon University Hospital, University of Athens School of Medicine, 76 Aigeou Pelagous Street, Agia Paraskevi, 15 341, Attica, 12462 Athens, Greece.
Telephone: +30-210-5326419
Received: May 24, 2015
Peer-review started: May 25, 2015
First decision: September 14, 2015
Revised: November 19, 2015
Accepted: December 9, 2015
Article in press: December 11, 2015
Published online: February 16, 2016
Core Tip

Core tip: Fine-needle aspiration (FNA) cytology is widely used for the diagnosis of thyroid nodules, although cases with indeterminate results are not rare. We reviewed the English literature regarding Thyroid Cytopathology systems in order to identify the most suitable methodology, taking into account our prospective as well. The Bethesda System for Reporting Thyroid Cytopathology is the most preferred system for the diagnosis of FNA specimens, which also contains guidelines for the diagnosis and treatment of indeterminate cases. Last but not least, repeated FNAs will lead to a diagnosis in 72%-80% of indeterminate cases where repeated FNAs were needed.