Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2015; 3(9): 793-806
Published online Sep 16, 2015. doi: 10.12998/wjcc.v3.i9.793
Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis
Jia-Ren Liu, Xiaohui Han, Sulpicio G Soriano, Koichi Yuki
Jia-Ren Liu, Xiaohui Han, Sulpicio G Soriano, Koichi Yuki, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, Boston, MA 02115, United States
Jia-Ren Liu, Xiaohui Han, Sulpicio G Soriano, Koichi Yuki, Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, United States
Author contributions: All the authors contributed to this paper.
Supported by CHMC Anesthesia Foundation (Soriano SG and Yuki K), William F. Milton Fund (Yuki K); and BCH Endowed Chair in Pediatric Neuroanesthesia (Soriano SG).
Institutional review board statement: The study was reviewed and approved by Boston Children’s Hospital Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Boston Children’s Hospital (protocol number 2218/2893).
Conflict-of-interest statement: None.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Koichi Yuki, MD, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, United States. koichi.yuki@childrens.harvard.edu
Telephone: +1-617-3556225 Fax: +1-617-7300894
Received: January 24, 2015
Peer-review started: February 1, 2015
First decision: March 6, 2015
Revised: April 10, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: September 16, 2015
Processing time: 104 Days and 20 Hours
Core Tip

Core tip: We report our result on the role of leukocyte function-associated antigen-1 (LFA-1) in polymicrobial abdominal sepsis model induced by cecal ligation and puncture. LFA-1 is a key player in neutrophil migration, but its role in neutrophil migration to tissues in polymicrobial sepsis is yet to be determined. This study demonstrated that LFA-1 deficiency blocked neutrophil migration to the abdominal cavity, but maintained migration to other organs, and reduced survival in sepsis.