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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2015; 3(9): 757-764
Published online Sep 16, 2015. doi: 10.12998/wjcc.v3.i9.757
Published online Sep 16, 2015. doi: 10.12998/wjcc.v3.i9.757
Vitamin K and hepatocellular carcinoma: The basic and clinic
Xia Jinghe, Iwata Ozaki, Division of Hepatology, Diabetology and Endocrinology, Department of Internal Medicine, Saga Medical School, Saga University, Saga 849-8501, Japan
Toshihiko Mizuta, Department of Medicine, Imari-Arita Kyoritu Hospital, Nishimatu-ura County, Saga 849-4193, Japan
Iwata Ozaki, Health Administration Center, Saga University, Saga 849-8501, Japan
Author contributions: All three authors participated to write the significant parts of this paper and contributed to generate the basic and clinical data cited in references from our laboratory; Ozaki I made the figure and supervised the written manuscript.
Conflict-of-interest statement: All three authors have nothing to disclose regarding the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Iwata Ozaki, MD, PhD, Health Administration Center, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. ozaki@cc.saga-u.ac.jp
Telephone: +81-952-343215 Fax: +81-952-342096
Received: April 25, 2015
Peer-review started: May 4, 2015
First decision: June 3, 2015
Revised: June 20, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: September 16, 2015
Peer-review started: May 4, 2015
First decision: June 3, 2015
Revised: June 20, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: September 16, 2015
Core Tip
Core tip: Vitamin K (VK) is essential nutrient initially identified as a cofactor to produce functional coagulation factors. In addition to the roles in hemostasis, pleiotropic effects of VK in bone health, atherosclerotic diseases and cancer have been attracting. VK has been shown to play tumor-suppressive roles in several cancers including hepatocellular carcinoma (HCC) and reported to have beneficial effects in the treatment of HCC although its anti-tumor effects remain to be improved. Currently novel VK derivatives are under developing and will be applied to cancer treatment in the future.