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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2015; 3(6): 519-524
Published online Jun 16, 2015. doi: 10.12998/wjcc.v3.i6.519
Published online Jun 16, 2015. doi: 10.12998/wjcc.v3.i6.519
Advanced Anderson-Fabry disease presenting with left ventricular apical aneurysm and ventricular tachycardia
Marie-France Poulin, Alap Shah, Richard G Trohman, Christopher Madias, Department of Medicine, Division of Cardiology, Rush University Medical Center, Chicago, IL 60612, United States
Author contributions: Poulin MF, Shah A, Trohman RG and Madias C designed the report and contributed to the writing and editing of the paper; Poulin MF and Shah A collected the clinical data.
Supported by Rush University Medical Center, Chicago, IL, United States.
Ethics approval: Rush University Medical Center Institutional Board Review.
Informed consent: The patient gave her verbal informed consent prior to study inclusion.
Conflict-of-interest: All authors have no conflict of to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Christopher Madias, MD, Department of Medicine, Division of Cardiology, Rush University Medical Center, 1750 W. Harrison Street, Suite 985 Jelke, Chicago, IL 60612, United States. christopher_madias@rush.edu
Telephone: +1-312-9426858 Fax: +1-312-9425862
Received: October 20, 2014
Peer-review started: October 20, 2014
First decision: November 14, 2014
Revised: February 6, 2015
Accepted: March 18, 2015
Article in press: March 20, 2015
Published online: June 16, 2015
Peer-review started: October 20, 2014
First decision: November 14, 2014
Revised: February 6, 2015
Accepted: March 18, 2015
Article in press: March 20, 2015
Published online: June 16, 2015
Core Tip
Core tip: Left ventricular apical aneurysm (LVAA) is a very rare phenomenon in patients with Anderson-Fabry disease (AFD); however, this patient with genetically confirmed AFD presented with a new LVAA. The authors believe that formation of the LVAA is the result of long-standing elevated intra-cavitary systolic pressures and possibly genetic predisposition, similar to what can be seen in hypertrophic cardiomyopathy.