Prospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2015; 3(4): 360-367
Published online Apr 16, 2015. doi: 10.12998/wjcc.v3.i4.360
Efficacy of different doses of sugammadex after continuous infusion of rocuronium
Diego Soto Mesa, Mounir Fayad Fayad, Laura Pérez Arviza, Verónica Del Valle Ruiz, Fernando Cosío Carreño, Luis Arguelles Tamargo, Manuel Amorín Díaz, Sergio Fernández-Pello Montes
Diego Soto Mesa, Mounir Fayad Fayad, Laura Pérez Arviza, Verónica Del Valle Ruiz, Fernando Cosío Carreño, Luis Arguelles Tamargo, Department of Anaesthesiology, Hospital of Cabueñes, 33394 Gijón, Spain
Manuel Amorín Díaz, Department of Neurology, Hospital of Jove, Eduardo Castro s/n, 33290 Gijón, Spain
Sergio Fernández-Pello Montes, Department of Urology, Hospital of Cabueñes, 33394 Gijón, Spain
Author contributions: All authors contributed equally to this work; all authors designed the study, performed the research and contributed new reagents/analytic tools; Fayad Fayad M and Amorín Díaz M analyzed the data; Soto Mesa D and Amorín Díaz M wrote the paper; and all authors revised the manuscript for final submission.
Ethics approval: The study was reviewed and approved by the “ComitéÉtico de Investigación Clínica Regional del Principado de Asturias”.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: The authors declare that they have no personal conflict of interest. The translation of the manuscript has been supported by Merck Sharp and Dohme (MSD) Spain.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Diego Soto Mesa, MD, Department of Anaesthesiology, Hospital of Cabueñes, C/Los Prados 395, 33394 Gijón, Spain.
Telephone: +34-62-0594074
Received: October 30, 2014
Peer-review started: October 30, 2014
First decision: December 26, 2014
Revised: January 28, 2015
Accepted: February 10, 2015
Article in press: February 12, 2015
Published online: April 16, 2015
Core Tip

Core tip: The release of sugammadex in recent times has been a global shift in the strategy of the reversal of neuromuscular blockade (NMB) induced by aminosteroid neuromuscular blocking. The use of this drug has been increasing slowly, and consequently, we receive more and more questions in regards to its efficacy and safety. In this study we compared the dose of 2 mg/kg to 4 mg/kg sugammadex to reverse the NMB when first response in the train-of-four is reached after continuous infusion of rocuronium. Both doses have been shown to be effective for recovery from NMB.