Minireviews
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2015; 3(3): 293-300
Published online Mar 16, 2015. doi: 10.12998/wjcc.v3.i3.293
Voltage gated calcium channel antibody-related neurological diseases
Can Ebru Bekircan-Kurt, Eda Derle Çiftçi, Aslı Tuncer Kurne, Banu Anlar
Can Ebru Bekircan-Kurt, Aslı Tuncer Kurne, Neurology Department, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
Eda Derle Çiftçi, Neurology Department, Faculty of Medicine, Başkent University, 06490 Ankara, Turkey
Banu Anlar, Pediatric Neurology Department, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
Author contributions: All authors contributed to this work.
Conflict-of-interest: We certify that there is no actual or potential conflict of interest in relation to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Can Ebru Bekircan-Kurt, MD, Neurology Department, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey. canebru@yahoo.co.uk
Telephone: +90-53-32249252
Received: July 25, 2014
Peer-review started: July 27, 2014
First decision: November 27, 2014
Revised: December 15, 2014
Accepted: January 9, 2015
Article in press: January 15, 2015
Published online: March 16, 2015
Processing time: 230 Days and 16.6 Hours
Core Tip

Core tip: Voltage gated calcium channel (VGCC) antibodies are generally associated with Lambert-Eaton myasthenic syndrome, but also with paraneoplastic or non-paraneoplastic cerebellar degeneration. The autoimmune nature of non-tumour Lambert-Eaton myasthenic syndrome is reflected in its association with various HLA subtypes and other autoimmune diseases such as vitiligo, myasthenia gravis and diabetes mellitus. The most common tumour associated with VGCC-antibody-positivity is small cell lung cancer. Knowledge on the relation between cerebellar degeneration and VGCC is limited, and treatment response is poor in this group of patients.