Published online Feb 16, 2014. doi: 10.12998/wjcc.v2.i2.27
Revised: December 9, 2013
Accepted: December 17, 2013
Published online: February 16, 2014
Core tip: The demonstration of a lesion or disease involving the somatosensory system is mandatory for the diagnosis of definite neuropathic pain. Unfortunately, none of the currently available methods is suitable for every type of nerve lesion. Neurodiagnostic skin biopsy (NSB) is an objective method to measure the density of epidermal sensory small fibers. In case of unilateral nerve lesions, it goes beyond the diagnostic possibilities of neurophysiological tests, allowing the diagnosis of axonal neuropathies of peripheral nerves supplying every body part covered by skin. For these reasons, NSB represents a precious tool for the diagnosis of peripheral unilateral neuropathic pain.