Case Report
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World J Clin Cases. Dec 16, 2014; 2(12): 912-917
Published online Dec 16, 2014. doi: 10.12998/wjcc.v2.i12.912
Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other?
Ibolya File, Csilla Trinn, Zsolt Mátyus, László Ujhelyi, József Balla, János Mátyus
Ibolya File, Csilla Trinn, László Ujhelyi, József Balla, János Mátyus, Institute of Internal Medicine, University of Debrecen, Clinical Centre, H-4032 Debrecen, Hungary
Zsolt Mátyus, Borsod-Abaúj-Zemplén County and University Teaching Hospital, 2nd Department of Internal Medicine, H-3526 Miskolc, Hungary
Author contributions: Mátyus J designed the report; Ujhelyi L performed the renal biopsies; File I, Trinn C, Mátyus Z, Balla J and Mátyus J collected the patient’s clinical data; File I, Trinn Cs, and Mátyus J analyzed the data and wrote the paper.
Supported by Department of Nephrology, University of Debrecen, Clinical Centre, Debrecen, Hungary; The project implemented through the New Hungary Development Plan, co-financed by the European Union and the European Social Fund, No. TÁMOP-4.2.2.A-11/1/KONV-2012-0045
Correspondence to: Ibolya File, MD, Institute of Internal Medicine, University of Debrecen, Clinical Centre, 98 Nagyerdei bld., H-4032 Debrecen, Hungary. fileibolya@gmail.com
Telephone: +36-20-5145005
Received: July 28, 2014
Revised: October 2, 2014
Accepted: October 23, 2014
Published online: December 16, 2014
Core Tip

Core tip: Relapsing polychondritis (RP) is a rare disease usually diagnosed late when serious symptoms occur. Appearance of renal symptoms significantly increases the possibility of associated associated vasculitis (AAV). We present three cases of RP in whom AAV occurred at different times during the illness. AAV caused rapidly progressive glomerulonephritis (RPGN) in the second and third patient. Aggressive immunosuppression resulted in remission of both RP and AAV. In the RPGN cases dialysis could be discontinued.