Vyas R, Zargar H, Trolio RD, Lorenzo GD, Autorino R. Squamous cell carcinoma of the scrotum: A look beyond the chimneystacks. World J Clin Cases 2014; 2(11): 654-660 [PMID: 25405188 DOI: 10.12998/wjcc.v2.i11.654]
Corresponding Author of This Article
Riccardo Autorino, MD, PhD, FEBU, Urology Institute, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, United States. ricautor@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
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World J Clin Cases. Nov 16, 2014; 2(11): 654-660 Published online Nov 16, 2014. doi: 10.12998/wjcc.v2.i11.654
Squamous cell carcinoma of the scrotum: A look beyond the chimneystacks
Ritva Vyas, Homayoun Zargar, Rossella Di Trolio, Giuseppe Di Lorenzo, Riccardo Autorino
Ritva Vyas, Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH 44106, United States
Homayoun Zargar, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OU 44195, United States
Rossella Di Trolio, Unit of Medical Oncology and Innovative Therapy, National Cancer Institute “Fondazione Giovanni Pascale”, 80100 Napoli, Italy
Giuseppe Di Lorenzo, Genitourinary Cancer Section and Rare-Cancer Center, Medical Oncology Division, University Federico II, 80100 Napoli, Italy
Riccardo Autorino, Urology Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, United States
Riccardo Autorino, Urology Unit, Second University of Naples, 80100 Naples, Italy
Author contributions: All authors contributed to this paper.
Correspondence to: Riccardo Autorino, MD, PhD, FEBU, Urology Institute, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, United States. ricautor@gmail.com
Telephone: +1-440-5168700 Fax: +1-216-2015276
Received: June 11, 2014 Revised: August 23, 2014 Accepted: September 16, 2014 Published online: November 16, 2014 Processing time: 152 Days and 9.2 Hours
Core Tip
Core tip: Scrotal squamous cell carcinoma (SCC) although rare, represents one of the most common forms of scrotal malignancy. The epidemiology of SCC has changed over time and iatrogenic conditions (psoralens and ultraviolet A radiation, immunosuppression, etc.) and human papilloma virus infection play a significant role as associated conditions. Surgery is the cornerstone of treatment and primary excision with a risk stratified approach for staging and treatment of regional lymph node is advisable. Sentinel lymph node biopsy can mitigate the morbidities of unwarranted inguinal lymph node dissection in selected cases. For locally advanced and metastatic disease palliative chemotherapy is advocated. Targeted therapies might hold promise for management of advanced SCC.
