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World J Clin Cases. Jan 16, 2014; 2(1): 16-19
Published online Jan 16, 2014. doi: 10.12998/wjcc.v2.i1.16
Published online Jan 16, 2014. doi: 10.12998/wjcc.v2.i1.16
Two rare cases of benign hyperlipasemia in children
Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy
Ruggiero Francavilla, Department of Paediatrics, University of Bari, 70100 Bari, Italy
Author contributions: Lionetti E, Francavilla R, Leonardi S, Tomarchio S, Gennaro A, Franzonello C and La Rosa M contributed to the acquisition of data; Lionetti E, Leonardi S, Tomarchio S, Gennaro A and Franzonello C drafted the report; all authors contributed to the revision of the report.
Correspondence to: Elena Lionetti, MD, Department of Medical and Pediatric Science, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy. elenalionetti@inwind.it
Telephone: +39-95-3782939 Fax: +39-95-3782385
Received: October 6, 2013
Revised: November 5, 2013
Accepted: December 9, 2013
Published online: January 16, 2014
Revised: November 5, 2013
Accepted: December 9, 2013
Published online: January 16, 2014
Core Tip
Core tip: Benign hyperlipasemia is a rare condition in children. The identification of this condition could be very useful for pediatricians in the diagnosis and management of hyperlipasemia. The cause of pancreatic hyperenzymemia seems to be related to a defected pathway from the trans-Golgi network to basolateral cell membrane. It has been hypothesized that a defect in this pathway could be responsible for the increased passage of enzymes into circulation. “Gullo’s syndrome” remains a diagnosis of exclusion and clinicians still need to be vigilant of the wide-ranging conditions that can manifest initially with elevations in lipase/amylase.