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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2025; 13(9): 99421
Published online Mar 26, 2025. doi: 10.12998/wjcc.v13.i9.99421
Published online Mar 26, 2025. doi: 10.12998/wjcc.v13.i9.99421
Small cell lung cancer with peripheral neuropathy as the first symptom: Two case reports
Man Luo, Dan-Yang Meng, Jin Hu, Department of Neurology, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Xiao-Xi Lu, Department of Information Technology, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Co-corresponding authors: Dan-Yang Meng and Jin Hu.
Author contributions: Meng DY and Lu XX prepared the material; Luo M and Hu J wrote the first draft; Meng DY and Hu J guided the study, reviewed the data and draft, they contributed equally as co-corresponding authors; and all authors contributed to the study conception and design, reviewed and approved the final manuscript.
Supported by Science and Technology Plan Project of Jiaxing, No. 2021AD30044; Supporting Discipline of Neurology in Jiaxing, No. 2023-ZC-006; and Affiliated Hospital of Jiaxing University, No. 2020-QMX-16.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Yang Meng, MD, Department of Neurology, Affiliated Hospital of Jiaxing University, No. 1882 Zhonghuan South Road, Nanhu District, Jiaxing 314000, Zhejiang Province, China. danyang_meng@163.com
Received: July 22, 2024
Revised: October 15, 2024
Accepted: November 26, 2024
Published online: March 26, 2025
Processing time: 142 Days and 23.6 Hours
Revised: October 15, 2024
Accepted: November 26, 2024
Published online: March 26, 2025
Processing time: 142 Days and 23.6 Hours
Core Tip
Core Tip: Paraneoplastic peripheral neuropathy is more common in patients with small cell lung cancer (SCLC), but the exact role of peripheral nerve symptoms and electromyography (EMG) in SCLC is still the subject of debate and research. At present, there are few reports of SCLC with peripheral nerve injury as the first symptom and EMG results. This article reports two cases of SCLC with limb numbness and weakness as the initial symptoms, highlighting the potential role of paraneoplastic peripheral nerve status and EMG in SCLC screening and the possible clinical correlation between them.