Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2025; 13(9): 101363
Published online Mar 26, 2025. doi: 10.12998/wjcc.v13.i9.101363
Ulcerative colitis and bullous pemphigoid: Direct association or a medication side effect: A case report
Gaelle-Christie Haddad, Anthony El Dada, Sergio Sbeih, Tony Kazzi, Karam Karam, Louis A Chaptini
Gaelle-Christie Haddad, Anthony El Dada, Sergio Sbeih, Tony Kazzi, Department of Internal Medicine, University of Balamand, Beirut 100, Lebanon
Karam Karam, Louis A Chaptini, Department of Medicine, Gastroenterology, University of Balamand, Balamand 100, Lebanon
Louis A Chaptini, Department of Medicine, Digestive Diseases, Yale School of Medicine, New Haven, CT 06510, United States
Co-first authors: Gaelle-Christie Haddad and Anthony El Dada.
Author contributions: Haddad GC, El Dada A, Sbeih S, Kazzi T, Karam K wrote the first draft and contributed to manuscript conceptualization, data curation, and investigation; Chaptini LA edited the first draft and supervised the work and he is the manuscript guarantor.
Informed consent statement: Written informed consent was obtained from the patients to publish this report in accordance with the journal’s patient consent policy.
Conflict-of-interest statement: No author states to have any conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Louis A Chaptini, MD, Assistant Professor, Department of Medicine, Digestive Diseases, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06510, United States. louis.chaptini@yale.edu
Received: September 11, 2024
Revised: October 27, 2024
Accepted: November 19, 2024
Published online: March 26, 2025
Processing time: 91 Days and 11.3 Hours
Core Tip

Core Tip: Physicians should be aware of the possibility that bullous pemphigoid (BP) could develop in patients with ulcerative colitis (UC). Although it is not listed as a known extraintestinal manifestation in UC, BP should be kept on the differential diagnosis list when patients with UC develop a skin condition. Whether BP is associated with UC or its treatment remains unclear. The fact that different agents have been incriminated in several reports makes the possibility of an association with the disease itself, rather than its treatment, more plausible.