Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2025; 13(6): 98111
Published online Feb 26, 2025. doi: 10.12998/wjcc.v13.i6.98111
Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports
Jin-Bok Hwang, Hyo-Jeong Jang
Jin-Bok Hwang, Hyo-Jeong Jang, Department of Pediatrics, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, South Korea
Author contributions: Hwang JB was responsible for conceptualization, funding acquisition, and writing original draft; Hwang JB and Jang HJ were responsible for data curation, formal analysis, investigation, methodology, validation, visualization, writing review and editing; all authors have read and approved the final manuscript.
Supported by The Keimyung University Dongsan Medical Center in 2006.
Informed consent statement: This study was approved by the Keimyung University Dongsan Medical Center Institutional Review Board (No. 2022-05-103). Informed consent was waived because of the retrospective nature of the study.
Conflict-of-interest statement: Hwang JB reports that this work was supported by the research promoting grant from the Keimyung University Dongsan Medical Center in 2006. The other author has no conflict-of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyo-Jeong Jang, MD, Associate Professor, Doctor, Department of Pediatrics, Keimyung University School of Medicine, Dongsan Medical Center, Dalgubeol-daero 1035, Dalseo-gu, Daegu 42601, South Korea. polarisjay@dsmc.or.kr
Received: June 18, 2024
Revised: September 12, 2024
Accepted: November 12, 2024
Published online: February 26, 2025
Processing time: 160 Days and 1.2 Hours
Core Tip

Core Tip: Saccharomyces boulardii (S. boulardii), one of the most commonly prescribed and generally safe probiotic for children, can trigger food protein-induced enterocolitis syndrome (FPIES) in patients with non-immunoglobulin E (IgE)-mediated or IgE-mediated food allergic reaction. Here, a new FPIES entity of healthy infants is described, in which acute FPIES is triggered solely by S. boulardii without any hypersensitivity to cow’s milk, soy, or complementary foods during follow-up. Those seven cases suggest that S. boulardii should be prescribed cautiously even in healthy children without FPIES to other foods.