Life-course management of gestational diabetes mellitus: A narrative review

doi:10.12998/wjcc.v13.i29.111096

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Oct 16, 2025 (publication date) through Sep 3, 2025

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World Journal of Clinical Cases

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2307-8960

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World J Clin Cases. Oct 16, 2025; 13(29): 111096
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.111096

Life-course management of gestational diabetes mellitus: A narrative review

Qing-Jing Luo, Qiang Ni

Qing-Jing Luo, Qiang Ni, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

Qing-Jing Luo, Qiang Ni, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, Sichuan Province, China

Author contributions: Luo QJ and Ni Q designed the research study; Luo QJ conducted the literature review and drafted the manuscript; Ni Q supervised the study, critically revised the manuscript, and approved the final version.

Conflict-of-interest statement: All the authors declare that they have no conflicts of interest related to this work.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Check-list.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Qiang Ni, Researcher, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 17 Section 3, Renmin South Road, Chengdu 610041, Sichuan Province, China. 18581843156@163.com

Received: June 23, 2025
Revised: July 5, 2025
Accepted: August 13, 2025
Published online: October 16, 2025
Processing time: 66 Days and 19 Hours

Core Tip

Core Tip: This narrative review explores the latest evidence on gestational diabetes mellitus (GDM), emphasizing its pathophysiology, clinical management, and long-term cardiometabolic consequences. It highlights the role of early hyperglycemia, epigenetic fetal programming, and GDM heterogeneity. The review advocates for precision medicine, life-course management, and context-sensitive postpartum care. It also outlines structural barriers to follow-up in low-resource settings and provides a roadmap for individualized prevention strategies aimed at interrupting intergenerational disease transmission.