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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2025; 13(29): 110948
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.110948
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.110948
Epidemiology, pathophysiology, and interventions for postpartum depression: Systematic review
Qing-Qing Ji, Meng-Yi Wang, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Qing-Qing Ji, Meng-Yi Wang, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, Sichuan Province, China
Author contributions: Ji QQ and Wang MY designed the research study; Ji QQ conducted the literature review and drafted the manuscript; Wang MY supervised the study, critically revised the manuscript, and approved the final version.
Conflict-of-interest statement: All authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng-Yi Wang, Researcher, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), No. 20 Section 3, Renmin South Road, Chengdu 610041, Sichuan Province, China. 18583986082@163.com
Received: June 19, 2025
Revised: June 30, 2025
Accepted: July 24, 2025
Published online: October 16, 2025
Processing time: 70 Days and 19.4 Hours
Revised: June 30, 2025
Accepted: July 24, 2025
Published online: October 16, 2025
Processing time: 70 Days and 19.4 Hours
Core Tip
Core Tip: This systematic review synthesizes recent evidence on postpartum depression, highlighting its multifactorial etiology involving hormonal, inflammatory, and psychosocial mechanisms. It evaluates emerging interventions including cognitive behavioral therapy, community-based models, and GABAergic modulation. The review proposes a stepped-care framework integrating biological risk stratification, culturally adapted tools, and digital delivery platforms, aiming to advance equitable and personalized maternal mental health care globally.