Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2025; 13(26): 108409
Published online Sep 16, 2025. doi: 10.12998/wjcc.v13.i26.108409
Solitary extramedullary plasmacytoma mimicking ocular surface squamous neoplasia in an elderly male: A case report
Thilakraj Koppalu Lingaraju, Bijnya Birajita Panda, Madhusmita Sethy, Sri Lasya Achanta
Thilakraj Koppalu Lingaraju, Sri Lasya Achanta, Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneshwar 751019, Odisha, India
Bijnya Birajita Panda, Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India
Madhusmita Sethy, Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneshwar 751019, Odisha, India
Author contributions: Bijnya P designed and conducted the study; Thilakraj KL wrote the manuscript; Bijnya P provided clinical inputs and critically analyzed the manuscript; Thilakraj KL acquired the clinical data, prepared the first draft of the manuscript, searched the literature, and was responsible for the preparation of figures; Panda BB critically analyzed the initial manuscript and provided crucial inputs that were essential for preparing the final version of the manuscript; Madhusmita S provided histopathological data and figure preparation and critically analyzed the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bijnya Birajita Panda, Assistant Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Sijua, Bhubaneswar 751019, Odisha, India. bigyan_panda@yahoo.co.in
Received: April 14, 2025
Revised: May 18, 2025
Accepted: June 13, 2025
Published online: September 16, 2025
Processing time: 100 Days and 24 Hours
Core Tip

Core Tip: Conjunctival plasmacytoma is a rare extra medullary manifestation of multiple myeloma that can clinically mimic ocular surface squamous neoplasia. This case highlights the importance of including multiple myeloma in the differential diagnosis of atypical conjunctival masses, especially in patients with a known history of the disease, to enable accurate diagnosis and timely intervention.