Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2025; 13(24): 107825
Published online Aug 26, 2025. doi: 10.12998/wjcc.v13.i24.107825
Segmental atrophy of the liver: Review of a rare pseudotumor
Ayesha Younus, Yu Liu, Ellen E Connor, Zeng-Ying Wu, Hwajeong Lee, Zhi-Yan Fu
Ayesha Younus, Yu Liu, Ellen E Connor, Zhi-Yan Fu, Department of Pathology, LSU Health Sciences Center School of Medicine, New Orleans, LA 70112, United States
Zeng-Ying Wu, Clinical Volunteer Service, University Medical Center, New Orleans, LA 70112, United States
Hwajeong Lee, Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United States
Co-first authors: Ayesha Younus and Yu Liu.
Author contributions: All authors have contributed to the manuscript and agree with the final version of the manuscript; Younus A, Liu Y and Fu Z are credited with significant contribution to the drafting of the work, literature review of all the sections discussed, the revision of critically important intellectual content, final approval of the published version, and agreement of accountability for all aspects of the work; Wu Z and Lee H are credited with literature review of all sections, and agreement of accountability for all parts of the work; Connor E is credited with assisting in final content language polishing, and agreement of accountability for all aspects of the work.
Conflict-of-interest statement: All authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Yan Fu, MD, Assistant Professor, Department of Pathology, LSU Health Sciences Center School of Medicine, 1901 Perdido St, New Orleans, LA 70112, United States. zfu@lsuhsc.edu
Received: March 31, 2025
Revised: April 21, 2025
Accepted: May 13, 2025
Published online: August 26, 2025
Processing time: 79 Days and 10.2 Hours
Core Tip

Core Tip: Segmental atrophy (SA) of the liver is a rare pseudotumor that typically presents as a liver mass mimicking a neoplasm. It is usually asymptomatic and most often discovered incidentally. SA is more commonly seen in female patients, with an average age of 59.6 years. The exact pathogenesis remains poorly understood, though it is strongly associated with vascular injury. Histopathologically, the lesion progresses through several stages, ranging from parenchymal collapse to nodular elastosis and eventually nodular fibrosis. Recognizing these distinct morphologic stages is essential for accurate diagnosis.