Rates of p16 and p53 expression in head and neck cutaneous squamous cell carcinoma vary according to human papillomavirus status

doi:10.12998/wjcc.v13.i18.104313

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Jun 26, 2025 (publication date) through Mar 2, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 26, 2025; 13(18): 104313
Published online Jun 26, 2025. doi: 10.12998/wjcc.v13.i18.104313

Rates of p16 and p53 expression in head and neck cutaneous squamous cell carcinoma vary according to human papillomavirus status

Rachid Ait Addi

Rachid Ait Addi, Department of Biology, Independent Senior Researcher, Marrakesh 41020, Morocco

Author contributions: Ait Addi R was responsible for drafting and revision of the manuscript, read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Rachid Ait Addi, PhD, Assistant Professor, Senior Researcher, Department of Biology, Independent Senior Researcher, 1368 Rte Essaouira, N 03, Marrakesh 41020, Morocco. dr.rachid.aitaddi@gmail.com

Received: December 17, 2024
Revised: January 27, 2025
Accepted: February 8, 2025
Published online: June 26, 2025
Processing time: 72 Days and 12.9 Hours

Core Tip

Core Tip: In this editorial, we comment on a retrospective cohort study published in the recent issue of the World Journal of Clinical Cases. The authors of this article aimed to highlight that p16, commonly used as a surrogate marker for human papillomavirus in oropharyngeal squamous cell carcinoma (SCC), is not a reliable indicator in head and neck cutaneous SCC. This finding offers important insights for future research focusing on Asian populations.