Liu AN, Yang JY, Chen XY, Wu SS, Ji Zhi SN, Zheng SM. Refractory Crohn's disease complicated with Guillain-Barré syndrome: A case report. World J Clin Cases 2025; 13(18): 103618 [DOI: 10.12998/wjcc.v13.i18.103618]
Corresponding Author of This Article
Shu-Mei Zheng, MD, Chief Physician, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zhengsm@163.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
A-Niu Liu, Department of Gastroenterology and Hepatology, Chengdu Medical College, Chengdu 610500, Sichuan Province, China
A-Niu Liu, Xing-Yu Chen, Shan-Shan Wu, Se-Niu Ji Zhi, Shu-Mei Zheng, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China
Jia-Yi Yang, Department of Radiology, Wuxi People’s Hospital, Nanjing Medical University, Nanjing 214023, Jiangsu Province, China
Author contributions: Zheng SM designed the report; Liu AN and Chen XY collected the patient’s clinical data; Yang JY and Liu AN analyzed the magnetic resonance imaging and computed tomography images; Wu SS and Ji Zhi SN analyzed the microscopy images; Liu AN and Zheng SM wrote the paper; Yang JY edited the English language version of the manuscript; and all authors have read and approved the final version to be published.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Mei Zheng, MD, Chief Physician, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zhengsm@163.com
Received: November 26, 2024 Revised: January 24, 2025 Accepted: February 17, 2025 Published online: June 26, 2025 Processing time: 94 Days and 2.5 Hours
Core Tip
Core Tip: Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory gastrointestinal disorders, including Crohn's disease (CD) and ulcerative colitis. The natural course of IBD can be accompanied by several extraintestinal manifestations. IBD combined with Guillain-Barré syndrome (GBS) has rarely been reported. Here, we describe a patient with refractory CD who stopped responding to multiple drugs and experienced recurrent complicated intestinal fistulas. After several abdominal surgeries and treatment with ustekinumab, he achieved clinical remission. Unfortunately, he developed GBS during maintenance therapy. In patients with IBD combined with GBS, GBS may be a comorbidity, an extraintestinal manifestation of IBD, or an adverse reaction to IBD therapeutic drugs. We suspected that GBS might have been a comorbidity in this patient; therefore, we decided to continue maintenance treatment with ustekinumab along with intravenous immunoglobulin, dexamethasone and traditional Chinese medicine acupuncture, which resulted in a steady improvement in his GBS symptoms and sustained remission of CD.
