Myrou AD, Spilioti MG, Tsolaki AC, Frontistis AN, Savopoulos CG. Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports. World J Clin Cases 2025; 13(16): 97716 [DOI: 10.12998/wjcc.v13.i16.97716]
Corresponding Author of This Article
Athena D Myrou, Doctor, MD, MSc, PhD, Consultant Physician-Scientist, Department of Internal Medicine, AHEPA University General Hospital, St Kyriakidi 1 street, Thessaloniki 54636, Greece. taniamyrou@gmail.com
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2025; 13(16): 97716 Published online Jun 6, 2025. doi: 10.12998/wjcc.v13.i16.97716
Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports
Athena D Myrou, Martha G Spilioti, Anthoula C Tsolaki, Antonis N Frontistis, Christos G Savopoulos
Athena D Myrou, Department of Internal Medicine, AHEPA University General Hospital, Thessaloniki 54636, Greece
Martha G Spilioti, Anthoula C Tsolaki, Antonis N Frontistis, Department of Neurology, AHEPA University General Hospital, Thessaloniki 54636, Greece
Christos G Savopoulos, Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University General Hospital, Thessaloniki 54636, Greece
Author contributions: Myrou AD designed the study, collected the patients’ clinical data, and wrote the draft of the manuscript; Tsolaki AC and Frontistis AN drafted the manuscript; Spilioti MG and Savopoulos CG revised the draft of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Informed consent statement: Informed consent was waived due to the cases having ended in death.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Athena D Myrou, Doctor, MD, MSc, PhD, Consultant Physician-Scientist, Department of Internal Medicine, AHEPA University General Hospital, St Kyriakidi 1 street, Thessaloniki 54636, Greece. taniamyrou@gmail.com
Received: June 5, 2024 Revised: September 4, 2024 Accepted: September 23, 2024 Published online: June 6, 2025 Processing time: 249 Days and 12.5 Hours
Core Tip
Core Tip: Limbic encephalitis (LE) can occur as a paraneoplastic symptom or in the absence of a malignancy. Paraneoplastic encephalopathies are rare neurological disorders associated with antineuronal antibodies. Symptoms include memory loss, impaired mental function, behavioral disorders, and epileptic seizures. Antibodies against extracellular antigens, such as gamma-aminobutyric acid (GABA) B receptor (GABABR), are associated with a higher risk of tumor development. Glutamic acid decarboxylase antibodies have been linked to several neurological syndromes, which are hypothesized to result from decreased GABA ergic transmission. This article presents two cases of GABABR antibody-related LE resulting from small cell lung carcinoma with neurological symptoms that were managed with intravenous immunoglobulin therapy.
