Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2025; 13(16): 102866
Published online Jun 6, 2025. doi: 10.12998/wjcc.v13.i16.102866
Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit
Teng Guo, Li-Ying Du, Ming-Feng Liu, Xia-Jin Zhou, Xin-Ran Chen
Teng Guo, Li-Ying Du, Ming-Feng Liu, Xia-Jin Zhou, Xin-Ran Chen, Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang 050011, Hebei Province, China
Author contributions: Guo T, Du LY, Liu MF, and Chen XR performed the research; Chen XR designed the research study; Zhou XJ and Guo T completed the analysis; Guo T and Chen XR wrote and edited the manuscript; All authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Key Project Plan of Health and Medical Science Research in Hebei Provincial Health Commission, No. 20190745.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The Fourth Hospital of Hebei Medical University, approval No. 2021KS031.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Ran Chen, Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Hebei Key Laboratory of Clinical Pharmacy, No. 12 Jiankang Road, Chang’an District, Shijiazhuang 050011, Hebei Province, China. 48101847@hebmu.edu.cn
Received: November 4, 2024
Revised: December 24, 2024
Accepted: January 9, 2025
Published online: June 6, 2025
Processing time: 101 Days and 0 Hours
Core Tip

Core Tip: Plasma concentration monitoring is essential for optimizing vancomycin therapy. This study investigated the relationship between clinical characteristics, pharmacokinetic parameters of vancomycin, specifically the trough concentration and area under the curve, and its efficacy and nephrotoxicity in Chinese patients in the intensive care unit to inform personalized vancomycin administration. The results showed that the effective and safe concentration interval for vancomycin for patients in the intensive care unit was a trough concentration of 9.4-14.0 μg/mL.