Relevant clinical factors for early extubation in living-donor liver transplantation: A single-center retrospective cohort study

doi:10.12998/wjcc.v13.i14.102693

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May 16, 2025 (publication date) through Jan 18, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Cases. May 16, 2025; 13(14): 102693
Published online May 16, 2025. doi: 10.12998/wjcc.v13.i14.102693

Relevant clinical factors for early extubation in living-donor liver transplantation: A single-center retrospective cohort study

Soeun Jeon, Dong Gun Lim, Hyunjee Kim, Seung-Bin You, Hye-Jin Kim, Jung-Pil Yoon, Kwangho Yang, Soon-Ji Park, Hyun-Su Ri

Soeun Jeon, Department of Anesthesia and Pain Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, South Korea

Dong Gun Lim, Hyunjee Kim, Hyun-Su Ri, Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea

Seung-Bin You, Hyun-Su Ri, Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Daegu 41944, South Korea

Hye-Jin Kim, Jung-Pil Yoon, Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, South Korea

Jung-Pil Yoon, Department of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Yangsan 50612, South Korea

Kwangho Yang, Department of Surgery, Pusan National University Yangsan Hospital, Yangsan 50612, South Korea

Kwangho Yang, Department of Surgery, Pusan National University, College of Medicine, Yangsan 50612, South Korea

Soon-Ji Park, Department of Anesthesia and Pain Medicine, Daedong Hospital, Busan 47737, South Korea

Author contributions: Jeon S and Ri HS contributed to the conceptualization of the manuscript, data collection, statistical analysis, original draft writing, and revising the manuscript; Lim DG, Kim HJ, You SB, and Yang K contributed to the analysis of the data, critical review of the manuscript for important intellectual content, and manuscript editing; Kim HJ, Yoon JP, Park SJ, and Ri HS were responsible for data collection and figure creation; Jeon S, Lim DG, Kim H, You SB, Kim HJ, Yoon JP, Yang K, Park SJ, and Ri HS critically reviewed and provided final approval of the manuscript; and all authors were responsible for the decision to submit the manuscript for publication.

Institutional review board statement: This study was approved by the Pusan National University Yangsan Hospital, approval No. 05-2021-196.

Informed consent statement: The informed consent was waived by the Institutional Review Board.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.

Data sharing statement: The data that support the findings of this study are available from the corresponding author, upon reasonable request.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hyun-Su Ri, Assistant Professor, MD, PhD, Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, No. 807 Hoguk-ro, Daegu 41944, South Korea. johnri@naver.com

Received: October 27, 2024
Revised: December 20, 2024
Accepted: January 3, 2025
Published online: May 16, 2025
Processing time: 81 Days and 14.3 Hours

Core Tip

Core Tip: This study identifies three relevant clinical factors of early extubation after living-donor liver transplantation (LDLT): Shorter anhepatic time, absence of high-dose vasoactive drugs at the end of surgery, and the use of epidural analgesia. These findings suggest that epidural analgesia may hold promise as a component of enhanced recovery protocols for patients undergoing LDLT. However, further research is needed to confirm safety across various coagulation profiles and to evaluate its broader impact on postoperative outcomes comprehensively.