Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2025; 13(1): 99746
Published online Jan 6, 2025. doi: 10.12998/wjcc.v13.i1.99746
Published online Jan 6, 2025. doi: 10.12998/wjcc.v13.i1.99746
Lipomatous ependymoma with ZFTA: RELA fusion-positive: A case report
Xiao-Yu Zhao, Yi-Hua Wang, Yi-Xin Liu, Lu Xu, China Medical University, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Juan-Han Yu, Lin Fu, Department of Pathology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Ning Yi, Anshan Cancer Hospital, Anshan 114000, Liaoning Province, China
Author contributions: Zhao XY conception and design of study, drafting of manuscript and critical revision; Yu JH conception and design of study, approval of final version of manuscript; All authors have read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan-Han Yu, MD, Associate Professor, Department of Pathology, The First Hospital of China Medical University, No. 155 Nanjing Bei Ave, Shenyang 110001, Liaoning Province, China. yujuanhan@foxmail.com
Received: July 29, 2024
Revised: October 3, 2024
Accepted: October 24, 2024
Published online: January 6, 2025
Processing time: 100 Days and 18.6 Hours
Revised: October 3, 2024
Accepted: October 24, 2024
Published online: January 6, 2025
Processing time: 100 Days and 18.6 Hours
Core Tip
Core Tip: Ependymoma with lipomatous differentiation is a rare type of ependymoma. The ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system tumors. ZFTA fusion-positive lipomatous ependymoma has not been reported to date. This case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation, and highlights the possibility that ZFTA fusion and lipomatous differentiation may co-occur, adding a new layer to the molecular classification of ependymomas.