Xu LL, Chen JX, Cheng JP, Luo N. Exogenous insulin autoimmune syndrome: A case report and review of literature. World J Clin Cases 2024; 12(9): 1691-1697 [PMID: 38576740 DOI: 10.12998/wjcc.v12.i9.1691]
Corresponding Author of This Article
Jing-Ping Cheng, Doctor, Chief Doctor, Department of Gerontology, CR & WISCO General Hospital Affiliated to Wuhan University of Science and Technology, No. 29 Metallurgy Avenue, Qingshan District, Wuhan 430080, Hubei Province, China. 404178516@qq.com
Research Domain of This Article
Gerontology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 26, 2024; 12(9): 1691-1697 Published online Mar 26, 2024. doi: 10.12998/wjcc.v12.i9.1691
Exogenous insulin autoimmune syndrome: A case report and review of literature
Ling-Ling Xu, Jia-Xin Chen, Jing-Ping Cheng, Ni Luo
Ling-Ling Xu, Jia-Xin Chen, Medical College, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, Hubei Province, China
Jing-Ping Cheng, Ni Luo, Department of Gerontology, CR & WISCO General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430080, Hubei Province, China
Co-first authors: Ling-Ling Xu and Jia-Xin Chen.
Co-corresponding authors: Jing-Ping Cheng and Ni Luo.
Author contributions: Xu LL wrote the manuscript; Chen JX proofread and verified the data in the manuscript; Cheng JP and Luo N screened patients and obtained clinical data and final reviewed the manuscript; All authors have read and approve the final manuscript. Xu LL summarized the data and wrote the first draft. Chen JX proof-collated the data and optimized the manuscript. Both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Both Cheng JP and Luo N have played important and indispensable roles in data interpretation and manuscript preparation as the co-corresponding authors. Cheng JP conceptualized, designed, and supervised the whole process of the project. Luo N was responsible for data re-analysis and re-interpretation, table drawing and ideas refining. This collaboration between Cheng JP and Luo N is crucial for the publication of this manuscript and other manuscripts still in preparation.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying tables.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Ping Cheng, Doctor, Chief Doctor, Department of Gerontology, CR & WISCO General Hospital Affiliated to Wuhan University of Science and Technology, No. 29 Metallurgy Avenue, Qingshan District, Wuhan 430080, Hubei Province, China. 404178516@qq.com
Received: January 24, 2024 Peer-review started: January 24, 2024 First decision: January 31, 2024 Revised: February 23, 2024 Accepted: March 6, 2024 Article in press: March 6, 2024 Published online: March 26, 2024 Processing time: 60 Days and 19 Hours
Core Tip
Core Tip: Exogenous insulin autoimmune syndrome (EIAS), also known as non-classical insulin autoimmune syndrome, occurs in individuals with type 2 diabetes who use exogenous insulin, resulting in the production of insulin autoantibodies and the subsequent development of hyperinsulinemia. This condition is characterized by significant fluctuations in blood glucose levels and insulin resistance. In patients with type 2 diabetes receiving treatment with oral medications or insulin therapy, episodes of hypoglycemia are often attributed to drug-related causes. Consequently, EIAS tends to be overlooked in clinical practice, particularly among elderly patients. Herein, we report a case of EIAS in an elderly person. Based on an analysis of PubMed cases, it has been observed that the disease tends to be self-limiting with a favorable prognosis.
