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World J Clin Cases. Feb 6, 2024; 12(4): 688-699
Published online Feb 6, 2024. doi: 10.12998/wjcc.v12.i4.688
Application and mechanisms of Sanhua Decoction in the treatment of cerebral ischemia-reperfusion injury
Ya-Kuan Wang, Huang Lin, Shu-Rui Wang, Ru-Tao Bian, Yang Tong, Wen-Tao Zhang, Ying-Lin Cui
Ya-Kuan Wang, Shu-Rui Wang, Department of Encephalopathy, The Second Clinical College of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
Ya-Kuan Wang, Department of Encephalopathy, Henan Provincial Hospital of Integrated Chinese and Western Medicine, Zhengzhou 450000, Henan Province, China
Huang Lin, Department of Traditional Chinese Medicine Classics, Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou 450000, Henan Province, China
Ru-Tao Bian, Department of Central Laboratory, Zhengzhou Traditional Chinese Medicine Hospital, Zhengzhou 450000, Henan Province, China
Yang Tong, Wen-Tao Zhang, Department of Encephalopathy, Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou 450000, Henan Province, China
Ying-Lin Cui, Famous Doctor Hall, Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou 450000, Henan Province, China
Author contributions: Cui YL and Zhang WT conceptualized this study; Wang YK and Wang SR contributed to the methodology; Bian RT and Tong Y validated the study; Wang SR and Lin H contributed to the data curation; Wang YK drafted the manuscript; Cui YL contributed to the manuscript writing, review and editing.
Supported by Key Project of Henan Provincial Administration of Traditional Chinese Medicine, No. 2017ZY1020; General Public Relations Project of Henan Provincial Department of Science and Technology, No. 212102311123; and General Research Project of the National Administration of Traditional Chinese Medicine, No. GZY-KJS-2021-017.
Conflict-of-interest statement: Authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Lin Cui, MM, Chief Doctor, Famous Doctor Hall, Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), No. 6 Dongfeng Road, Zhengzhou 450000, Henan Province, China. z9012xj@163.com
Received: November 22, 2023
Peer-review started: November 22, 2023
First decision: December 8, 2023
Revised: December 15, 2023
Accepted: January 8, 2024
Article in press: January 8, 2024
Published online: February 6, 2024
Processing time: 63 Days and 23.3 Hours
Core Tip

Core Tip: As a traditional Chinese medicinal formulation, Sanhua Decoction are mediated via different pathways, including antioxidant, anti-inflammatory, and neurotransmitter regulatory pathways, as well as through the protection of nerve cells and a reduction in cerebral edema. In this paper, we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the Sanhua Decoction.