Potential of traditional Chinese medicine lyophilized powder of Poecilobdella manillensis in the treatment of hyperuricemia

doi:10.12998/wjcc.v12.i36.6939

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Dec 26, 2024 (publication date) through Nov 28, 2024

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World Journal of Clinical Cases

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World J Clin Cases. Dec 26, 2024; 12(36): 6939-6943
Published online Dec 26, 2024. doi: 10.12998/wjcc.v12.i36.6939

Potential of traditional Chinese medicine lyophilized powder of Poecilobdella manillensis in the treatment of hyperuricemia

Kang-Ming Huang, Hong-Bin Chen, Jin-Rong Lin

Kang-Ming Huang, Hong-Bin Chen, Department of Gastroenterology, Sanming First Affiliated Hospital of Fujian Medical University, Sanming 365000, Fujian Province, China

Jin-Rong Lin, Department of Ultrasound imaging, The First Affiliated Hospital of Xiamen University, Xiamen 361000, Fujian Province, China

Author contributions: Huang KM contributed to the discussion and design of the manuscript; Huang KM and Lin JR participated in the writing, editing, and linguistic embellishment of the manuscript; Chen HB designed the overall concept and outlined the manuscript; Huang KM, Lin JR and Chen HB contributed equally to this paper; all of the authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hong-Bin Chen, BM BCh, Chief Physician, Department of Gastroenterology, Sanming First Affiliated Hospital of Fujian Medical University, No. 29 Liedong Street, Sanyuan District, Sanming 365000, Fujian Province, China. smchb2008@qq.com

Received: August 3, 2024
Revised: September 23, 2024
Accepted: October 15, 2024
Published online: December 26, 2024
Processing time: 88 Days and 16.8 Hours

Core Tip

Core Tip: Currently, there are still many limitations in the therapeutic drugs for hyperuricemia (HUA), and the side effects of drugs significantly restrict their clinical application. The total leech total protein (LTP) extracted from the Poecilobdella manillensis lyophilized powder from traditional Chinese medicine can reduce blood uric acid through multiple targets and channels. This paper demonstrates that whole LTP will be an important addition to the treatment of HUA in the future, and is expected to further promote the study of the role of LTP on the regulation of the gut microbiota and the serum metabolome, and provide new insights into the therapeutic strategy of HUA.