Wen NN, Sun LW, Geng Q, Zheng GH. Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies. World J Clin Cases 2024; 12(35): 6815-6825 [PMID: 39687638 DOI: 10.12998/wjcc.v12.i35.6815]
Corresponding Author of This Article
Guo-Hua Zheng, PhD, Professor, College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, No. 279 Zhouzhu Road, Pudong New District, Shanghai 201318, China. zhenggh@sumhs.edu.cn
Research Domain of This Article
Biology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 16, 2024; 12(35): 6815-6825 Published online Dec 16, 2024. doi: 10.12998/wjcc.v12.i35.6815
Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies
Na-Na Wen, Li-Wei Sun, Qian Geng, Guo-Hua Zheng
Na-Na Wen, Li-Wei Sun, Qian Geng, Guo-Hua Zheng, College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
Na-Na Wen, Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Author contributions: Wen NN was responsible for conceptualization, literature screening, data curation, extraction, methodology and writing original draft; Sun LW and Geng Q were responsible for literature screening, data curation, extraction and methodology; Zheng GH was responsible for conceptualization, methodology, project administration, supervision, writing original draft, writing review, and editing; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Hua Zheng, PhD, Professor, College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, No. 279 Zhouzhu Road, Pudong New District, Shanghai 201318, China. zhenggh@sumhs.edu.cn
Received: August 15, 2024 Revised: September 4, 2024 Accepted: September 25, 2024 Published online: December 16, 2024 Processing time: 70 Days and 1.7 Hours
Core Tip
Core Tip: A growing number of studies have reported changes in the composition and diversity of the gut microbiota between frail and healthy older adults, suggesting that alterations in the gut microbiota may play a key role in the pathophysiology of frailty; however, direct assessment of the associations between changes in the gut microbiome and frailty in older adults remains limited. This review revealed a significant decrease in α diversity and a significant increase in β diversity in frail older adults compared with non-frail older adults, which was commonly reflected by a reduction in beneficial species and an increase in pathogenic species. This study provides a comprehensive overview of the relationship between changes in the gut microbiota and frailty in older adults and suggests a possible role for the gut microbiota in the pathogenesis of frailty.
