Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2024; 12(30): 6391-6406
Published online Oct 26, 2024. doi: 10.12998/wjcc.v12.i30.6391
Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes
Yun-Chuan Yang, Xiang Ma, Chi Zhou, Nan Xu, Ding Ding, Zhong-Zheng Ma, Lei Zhou, Pei-Yuan Cui
Yun-Chuan Yang, Xiang Ma, Chi Zhou, Nan Xu, Ding Ding, Zhong-Zheng Ma, Lei Zhou, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China
Yun-Chuan Yang, Xiang Ma, Medical College, Jinan University, Guangzhou 510000, Guangdong Province, China
Pei-Yuan Cui, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China
Author contributions: Yang YC, Ma X, and Zhou C substantially contributed to the study conception and design and made revisions to the manuscript; Xu N, Ma ZZ, and Ding D were responsible for data collection, analysis, and manuscript writing; Zhou L and Cui PY made critical revisions; All authors assume full responsibility for the integrity and accuracy of the work, and any relevant queries were addressed and resolved appropriately, reviewed and approved the final manuscript.
Supported by School-Level Key Projects at Bengbu Medical College, No. 2021byzd109.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This is an open-access article that was selected by an in-house editor and comprehensively peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Pei-Yuan Cui, MD, Chief Doctor, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. cpy666@126.com
Received: May 7, 2024
Revised: July 3, 2024
Accepted: August 22, 2024
Published online: October 26, 2024
Processing time: 119 Days and 13 Hours
Core Tip

Core Tip: This study identified five hub genes (CD247, IL10, CCL5, CCL3, and STAT3) associated with primary biliary cholangitis (PBC) through comprehensive bioinformatics analysis. These hub genes were enriched in immune-related pathways and strongly correlated with immune cell infiltration in PBC. Although hub genes did not have a causal effect on PBC risk, they provided valuable insights into the molecular mechanisms of PBC and showed potential as biomarkers for PBC prediction and treatment.