Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2024; 12(3): 657-664
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.657
Primary anaplastic lymphoma kinase-positive large B-cell lymphoma of the left bulbar conjunctiva: A case report
Xiao-Hong Guo, Chu-Bin Li, Hui-Hui Cao, Gen-Yuan Yang
Xiao-Hong Guo, Chu-Bin Li, Hui-Hui Cao, Department of Pathology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, Guangdong Province, China
Gen-Yuan Yang, Endoscopy Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, Guangdong Province, China
Author contributions: Guo XH contributed to monitoring and drafted the original manuscript, collected the data and wrote the manuscript; Li CB contributed to patient follow-up and clinical data collection; Cao HH contributed to the diagnosis and data analysis; Yang GY contributed to conceptualization and supervision; All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CAREChecklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gen-Yuan Yang, MD, Associate Chief Physician, Doctor, Endoscopy Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Kangning Road, Zhuhai 519000, Guangdong Province, China. ygy19811104@163.com
Received: November 18, 2023
Peer-review started: November 18, 2023
First decision: December 5, 2023
Revised: December 17, 2023
Accepted: January 2, 2024
Article in press: January 2, 2024
Published online: January 26, 2024
Core Tip

Core Tip: Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (LBCL) is an aggressive and rare variant of diffuse LBCL. Herein, we report an uncommon case of stage IE extranodal ALK-positive LBCL initially originating in the bulbar conjunctiva. This case represents the first example of primary extranodal ALK-positive LBCL presenting as a bulbar conjunctival mass, which is extremely rare and shares morphological and immunohistochemical features with a variety of other neoplasms that can result in misdiagnosis. Awareness of the condition presented in this case report is necessary for early and accurate diagnosis and appropriate treatment.