Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2024; 12(3): 616-622
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.616
Brain abscess from oral microbiota approached by metagenomic next-generation sequencing: A case report and review of literature
Xue-Min Zhu, Chun-Xia Dong, Lei Xie, Hao-Xin Liu, Huai-Qiang Hu
Xue-Min Zhu, Lei Xie, Hao-Xin Liu, School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong Province, China
Chun-Xia Dong, Huai-Qiang Hu, Department of Neurology, the 960th Hospital of People′s Liberation Army, Jinan 250031, Shandong Province, China
Co-first authors: Xue-Min Zhu and Chun-Xia Dong.
Author contributions: Zhu XM and Dong CX analyzed and interpreted patient data and wrote the manuscript; Xie L and Liu HX interpreted the data and reread the manuscript to ensure it was intellectually sound; Hu HQ revised the manuscript for content, including content writing; Zhu XM and Dong CX contributed equally to this work as co-first authors; All authors have read and approve the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huai-Qiang Hu, MD, Doctor, Department of Neurology, the 960th Hospital of People′s Liberation Army, No. 25 Normal Road, Tianqiao District, Jinan 250031, Shandong Province, China. huhuaiqiang@126.com
Received: October 24, 2023
Peer-review started: October 24, 2023
First decision: November 28, 2023
Revised: December 16, 2023
Accepted: January 2, 2024
Article in press: January 2, 2024
Published online: January 26, 2024
Core Tip

Core Tip: Brain abscesses are mixed infections, and there is difficulty in detecting all pathogens on routine bacterial cultures. We report the case of a 54-year-old male with a brain abscess caused by oral bacteria. The patient recovered well after receiving a combination of metagenomic next-generation sequencing (mNGS)-assisted guided medication and surgery. mNGS may be used for the rapid diagnosis of pathogenic microorganisms and may play an important role in precision medicine.