Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2024; 12(3): 565-574
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.565
Marginal zone lymphoma with severe rashes: A case report
Si-Jun Bai, Ye Geng, Yi-Nan Gao, Cai-Xia Zhang, Qian Mi, Chen Zhang, Jia-Ling Yang, Si-Jie He, Zhen-Ying Yan, Jian-Xia He
Si-Jun Bai, Ye Geng, Yi-Nan Gao, Cai-Xia Zhang, Qian Mi, Chen Zhang, Jia-Ling Yang, Si-Jie He, Zhen-Ying Yan, Jian-Xia He, Department of Hematology, Shanxi Provincial People’s Hospital, Taiyuan 030012, Shanxi Province, China
Author contributions: Bai SJ and He JX were the main authors of the paper, and equally managed the case and drafted the manuscript; Geng Y, Gao YN, and Zhang CX acquired clinical data; Mi Q, Zhang C, Yang JL, He SJ, and Yan ZY were responsible for laboratory work, including HE staining, immunoassays and molecular analyses.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Xia He, PhD, Professor, Department of Hematology, Shanxi Provincial People’s Hospital, No. 29 Shuangtasi Street, Yingze District, Taiyuan 030012, Shanxi Province, China. hejianxia125@163.com
Received: September 8, 2023
Peer-review started: September 8, 2023
First decision: November 9, 2023
Revised: November 22, 2023
Accepted: January 3, 2024
Article in press: January 3, 2024
Published online: January 26, 2024
Processing time: 131 Days and 21.5 Hours
Core Tip

Core Tip: This paper reports a case of Marginal zone lymphoma (MZL) with generalized skin rashes accompanied by pruritus and purulent discharge. First-line treatment with rituximab combined with zanubrutinib had poor effects. However, after switching to obinutuzumab combined with zanubrutinib, the case was alleviated, and the rashes disappeared. Therefore, in patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody (mAb) combination therapy, switching to a type II anti-CD20 mAb combination regimen may be considered. This approach may provide a new perspective in the treatment of MZL.