Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2024; 12(3): 479-487
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.479
Significance of oxidative stress and antioxidant capacity tests as biomarkers of premature ovarian insufficiency: A case control study
Kaoru Kakinuma, Toshiyuki Kakinuma
Kaoru Kakinuma, Toshiyuki Kakinuma, Department of Obstetrics and Gynecology, International University of Health and Welfare Hospital, Tochigi 329-2763, Japan
Kaoru Kakinuma, Graduate School of Medicine, International University of Health and Welfare, Tokyo 107-8402, Japan
Author contributions: Kakinuma K and Kakinuma T were involved in conceptualizing the study, designing the methodology, validating the results, and performing formal analyses; They also conducted the investigation and curated the data for the research; Kakinuma K took the lead in writing the original draft of the manuscript; Both Kakinuma K and Kakinuma T contributed to reviewing and editing the manuscript to ensure its accuracy and clarity; They collaborated on visualizing the findings and providing supervision throughout the project; Kakinuma T handled project administration duties; Both authors have thoroughly reviewed the manuscript and have given their approval for its publication.
Institutional review board statement: This study was conducted with the approval of the ethics committee of our hospital (Ethics Review Committee, International University of Health and Welfare, approval number: 21-Im-075, approval date: 2022.3.22).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest related to the manuscript.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Toshiyuki Kakinuma, MD, PhD, Professor, Department of Obstetrics and Gynecology, International University of Health and Welfare Hospital, Iguchi, Nasushiobara, Tochigi 329-2763, Japan. tokakinuma@gmail.com
Received: August 25, 2023
Peer-review started: August 25, 2023
First decision: November 20, 2023
Revised: November 27, 2023
Accepted: January 2, 2024
Article in press: January 2, 2024
Published online: January 26, 2024
Processing time: 146 Days and 4.3 Hours
Core Tip

Core Tip: The majority of premature ovarian insufficiency (POI) cases are idiopathic. Regardless of the cause, the disease causes a rapid decrease in the number of remaining follicles in the ovary and causes extremely intractable infertility. The process leading to POI is marked by a decline in ovarian function, starting with incipient ovarian failure, then transitional ovarian failure, and finally POI. Diacron-reactive oxygen metabolites and oxidative stress index were considerably higher in the incipient ovarian failure and POI groups than in the control group, indicating that evaluating oxidative stress status may be useful for the early diagnosis of POI.