Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2024; 12(3): 474-478
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.474
Metabologenomics and network pharmacology to understand the molecular mechanism of cancer research
Yusuf Tutar
Yusuf Tutar, Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Division of Biochemistry, University of Health Sciences, Istanbul 34668, Turkey
Yusuf Tutar, Health Sciences Faculty, Recep Tayyip Erdogan University, Rize 53350, Turkey
Yusuf Tutar, Molecular Oncology Division, Health Sciences Institutes, University of Health Sciences, Istanbul 34668, Turkey
Yusuf Tutar, Molecular Medicine Division, Health Sciences Institutes, University of Health Sciences, Istanbul 34668, Turkey
Author contributions: Tutar Y prepared the manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yusuf Tutar, BSc, MSc, PhD, Academic Editor, Chairman, Dean, Full Professor, Science Editor, Senior Scientist, Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Division of Biochemistry, University of Health Sciences, Mekteb-i Tıbbiye-i Şahane (Hamidiye) Külliyesi Selimiye Mah Tıbbiye Cad, Istanbul 34668, Turkey. ytutar@outlook.com
Received: November 23, 2023
Peer-review started: November 23, 2023
First decision: November 28, 2023
Revised: December 7, 2023
Accepted: December 25, 2023
Article in press: December 25, 2023
Published online: January 26, 2024
Core Tip

Core Tip: Regulation of biochemical pathways is similar to Le Chatelier chemical dynamic equilibrium principle. It states that the equilibrium is disrupted by changing the conditions, and the position of dynamic equilibrium shifts to counteract the change to reestablish an equilibrium. Metabolites disrupt pathways either themselves or by enhancing gene expression levels. The equilibrium or “homeostasis” always reestablishes itself to survive the organism. The relationship between genes and metabolites may be discovered by understanding the link through computational networking.