Clinical Trials Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2024; 12(28): 6195-6203
Published online Oct 6, 2024. doi: 10.12998/wjcc.v12.i28.6195
Effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean section
Hong-Zhuan Chen, Yi Gao, Ke-Ke Li, Li An, Jing Yan, Hong Li, Jin Zhang
Hong-Zhuan Chen, Yi Gao, Ke-Ke Li, Li An, Jing Yan, Hong Li, Jin Zhang, Department of Anesthesiology, Hebei Key Laboratory of Maternal and Fetal Medicine, Shijiazhuang Key Laboratory of Reproductive Health, The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei Province, China
Author contributions: Chen HZ and Gao Y were responsible for conceptualization, methodology, writing original draft preparation; Li KK, An L, Yan J, and Li H were responsible for investigation, software, statistical analysis; Zhang J was responsible for reviewing and editing, funding acquisition, supervision; all authors read and approved the final manuscript.
Supported by the Project of Science and Technology Bureau of Shijiazhuang, Hebei Province, No. 201460823.
Institutional review board statement: This study was approved by the Institutional Ethics Committee of the Fourth Hospital of Shijiazhuang, No. 20200060.
Clinical trial registration statement: Have registered in ChiCTR2100052668.
Informed consent statement: Two informed consent forms were provided for verification.
Conflict-of-interest statement: There is no conflict of interest in this study, and all copyrights and intellectual property rights are relatively clear and have no disputes.
Data sharing statement: The data of this study can be publicly shared.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin Zhang, Doctor, Chief Physician, Department of Anesthesiology, Hebei Key Laboratory of Maternal and Fetal Medicine, Shijiazhuang Key Laboratory of Reproductive Health, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Chang'an District, Shijiazhuang 050000, Hebei Province, China. flx20210106@163.com
Received: March 4, 2024
Revised: June 10, 2024
Accepted: July 23, 2024
Published online: October 6, 2024
Processing time: 161 Days and 22.9 Hours
Core Tip

Core Tip: Esketamine, as an antagonist of the N-Methyl-D-Aspartate receptor, has been validated for pain control in surgical patients and has demonstrated efficacy in treating depression. Studies have indicated that the use of esketamine in postoperative pain pumps can improve short-term depression and pain outcomes. This study investigates the efficacy and safety of a single administration of esketamine during cesarean section, aiming to provide insights into the clinical application of esketamine for post-cesarean section pain management and the promotion of rapid postoperative recovery.