Velikova T, Aleksandrova A. Interferon-gamma release assays as a tool for differential diagnosis of gastrointestinal tuberculosis. World J Clin Cases 2024; 12(27): 6015-6019 [PMID: 39328852 DOI: 10.12998/wjcc.v12.i27.6015]
Corresponding Author of This Article
Anita Aleksandrova, MBBS, Medical Assistant, Department of Immunology, Medical-diagnostic laboratory Ramus, Georgi Dimitrov 44, Simitli 6000, Bulgaria. nikolovaanita96@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 26, 2024; 12(27): 6015-6019 Published online Sep 26, 2024. doi: 10.12998/wjcc.v12.i27.6015
Interferon-gamma release assays as a tool for differential diagnosis of gastrointestinal tuberculosis
Tsvetelina Velikova, Anita Aleksandrova
Tsvetelina Velikova, Medical Faculty, Sofia University Street Kliment Ohridski, Sofia 1407, Bulgaria
Anita Aleksandrova, Department of Immunology, Medical-diagnostic laboratory Ramus, Simitli 6000, Bulgaria
Co-first authors: Tsvetelina Velikova and Anita Aleksandrova.
Author contributions: Velikova T and Aleksandrova A wrote the paper; Velikova T revised the paper. Both authors approved the final version of the manuscript before submission.
Supported byThe European Union-Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria, Project, No. BG-RRP-2.004-0008.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anita Aleksandrova, MBBS, Medical Assistant, Department of Immunology, Medical-diagnostic laboratory Ramus, Georgi Dimitrov 44, Simitli 6000, Bulgaria. nikolovaanita96@gmail.com
Received: April 7, 2024 Revised: May 12, 2024 Accepted: June 7, 2024 Published online: September 26, 2024 Processing time: 114 Days and 5.9 Hours
Core Tip
Core Tip: The diagnosis of abdominal tuberculosis (TB) is frequently delayed since there are no identifiable clinical signs and symptoms, and the illness might resemble other intra-abdominal disorders. In line with this, the most prevalent causes of gastric outlet obstruction are peptic ulcer disease and stomach cancer, and when excluded, TB infection should be added as a differential diagnosis. Assays of interferon-gamma release (IGRAs) have become a crucial diagnostic tool for latent TB infection. IGRAs have also been used to potentially distinguish between mimics such as Crohn's disease or other ascites-causing conditions and abdominal TB. Given that they are unaffected by the Bacille Calmette-Guérin immunization, these are considered beneficial.
