Predictors of prognosis in Alzheimer’s disease: The role of cognitive dysfunction, immune abnormalities, and advanced neuroimaging

doi:10.12998/wjcc.v12.i27.6004

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Sep 26, 2024 (publication date) through Dec 28, 2024

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Sep 26, 2024; 12(27): 6004-6006
Published online Sep 26, 2024. doi: 10.12998/wjcc.v12.i27.6004

Predictors of prognosis in Alzheimer’s disease: The role of cognitive dysfunction, immune abnormalities, and advanced neuroimaging

Hafsa Arshad Raja, Abdulqadir J Nashwan

Hafsa Arshad Raja, Rawalpindi Medical University, Rawalpindi 46000, Pakistan

Abdulqadir J Nashwan, Department of Nursing, Hamad Medical Corporation, Doha 3050, Qatar

Author contributions: Raja HA contributed to the manuscript's writing, editing, and literature review; Nashwan AJ contributed to the manuscript's writing, editing, and literature review.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Abdulqadir J Nashwan, MSc, Research Scientist, Department of Nursing, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa

Received: February 5, 2024
Revised: May 18, 2024
Accepted: June 14, 2024
Published online: September 26, 2024
Processing time: 176 Days and 8.3 Hours

Core Tip

Core Tip: Alzheimer’s disease (AD) is a serious condition leading to cognitive and social challenges. A recent study found that poor prognosis in AD patients is linked to abnormal cellular immune function, extrapyramidal symptoms, altered consciousness, abnormal electroencephalogram, increased neutrophil-lymphocyte ratio, and severe pneumonia. Impaired cellular immune function, particularly reduced T lymphocytes in the blood, is an independent predictor of poor prognosis. Early and continuous use of AD medications is associated with better outcomes.