Orthopedic manifestations of Li-Fraumeni syndrome: Prevention and treatment of a polymorphic spectrum of malignancies

doi:10.12998/wjcc.v12.i26.5839

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Sep 16, 2024 (publication date) through Nov 24, 2024

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Sep 16, 2024; 12(26): 5839-5844
Published online Sep 16, 2024. doi: 10.12998/wjcc.v12.i26.5839

Orthopedic manifestations of Li-Fraumeni syndrome: Prevention and treatment of a polymorphic spectrum of malignancies

Giulia Cenci, Valerio Pace

Giulia Cenci, Department of Trauma and Orthopedics, Azienda Ospedaliera Santa Maria Hospital, Terni 05100, Italy

Valerio Pace, Department of Trauma and Orthopedics, AOSP Terni, Terni 05100, Italy

Author contributions: Pace V received the editorial invitation; Cenci G and Pace V designed the article, performed research and literature review, analyzed data, wrote and finalized the review.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Valerio Pace, MBBS, MSc, Researcher, Senior Research Fellow, Surgeon, Department of Trauma and Orthopedics, AOSP Terni, Via Joannuccio, Terni 05100, Italy. valeriopace@doctors.org.uk

Received: March 15, 2024
Revised: April 25, 2024
Accepted: May 22, 2024
Published online: September 16, 2024
Processing time: 129 Days and 9.9 Hours

Core Tip

Core Tip: Modern screening approaches, including comprehensive genetic testing and advanced imaging modalities, offer promising avenues for early detection and intervention, ultimately improving outcomes in individuals with Li-Fraumeni syndrome (LFS). We advocate the need for internationally recognized and standardized guidelines for diagnosis, treatment and follow up of LFS and the need to form an international multidisciplinary network able to provide the highest level of expertise.