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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2024; 12(25): 5681-5696
Published online Sep 6, 2024. doi: 10.12998/wjcc.v12.i25.5681
Published online Sep 6, 2024. doi: 10.12998/wjcc.v12.i25.5681
Differential expression of plasma cytokines in sepsis patients and their clinical implications
Hui-Xiu Liu, Interventional Diagnosis and Treatment Center, The Affiliated Second Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
Yu-Ying Wang, Department of Emergency, The Shanghai Putuo District People's Hospital, Shanghai 200060, China
Yu-Ying Wang, Xue-Feng Yang, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, China
Co-corresponding authors: Yu-Ying Wang and Xue-Feng Yang.
Author contributions: Wang YY, Yang XF, and Liu HX participated in the study design, analyze the data, and drafted the manuscript; Wang YY collected the samples; All authors have read and approve the final manuscript.
Supported by The Project of Hengyang Science and Technology Bureau , No. 202222035602 .
Institutional review board statement: The study was reviewed and approved by the Shanghai Putuo District People's Hospital (Approval No. 20220605).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Feng Yang, PhD, Professor, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, No. 336 Dongfeng South Road, Zhuhui District, Hengyang 421002, Hunan Province, China. yxf9988@126.com
Received: March 8, 2024
Revised: May 25, 2024
Accepted: July 1, 2024
Published online: September 6, 2024
Processing time: 129 Days and 20.7 Hours
Revised: May 25, 2024
Accepted: July 1, 2024
Published online: September 6, 2024
Processing time: 129 Days and 20.7 Hours
Core Tip
Core Tip: Clinically, sequential organ failure assessment (SOFA) or quick SOFA (qSOFA) scores are often used to identify and diagnose sepsis. However, some scholars have found that qSOFA scores are not good at predicting severe sepsis and mortality. Therefore, it is necessary to explore a new diagnostic method for sepsis. In this study, changes in plasma cytokine levels in patients with sepsis were assessed. We found that the serum levels of the cytokines interleukin16, granulocyte-macrophage colony-stimulating factor, CX3CL1, CXCL9, CXCL16, CCL25 and CCL23 were significantly increased in patients with sepsis, representing potential diagnostic biomarkers of sepsis.