Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2024; 12(24): 5492-5501
Published online Aug 26, 2024. doi: 10.12998/wjcc.v12.i24.5492
Correlation between TEX14 and ADAM17 expressions in colorectal cancer tissues of elderly patients and neoplasm staging, invasion, and metastasis
Gun Chen, Ling-Hua Cong, Chi-Jiang Gu, Ping Li
Gun Chen, Ling-Hua Cong, Ping Li, Department of Pathology, The Affiliated People’s Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China
Chi-Jiang Gu, Department of Gastrointestinal Surgery, The Affiliated People’s Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China
Author contributions: Chen G designed the research study; Chen G and Cong LH performed the research; Chen G, Gu CJ, and Li P analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of The Affiliated People's Hospital of Ningbo University (Approval No. 2020-NB-021032).
Informed consent statement: Patients were not required to provide informed consent for the study because the analysis used anonymous clinical data that were obtained after each patient agreed to the treatment through written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No other data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https: //creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gun Chen, BMed, Associate Chief Physician, Department of Pathology, The Affiliated People's Hospital of Ningbo University, No. 251 Baizhang Street, Yinzhou District, Ningbo 315000, Zhejiang Province, China. nbmike0139@163.com
Received: April 30, 2024
Revised: June 6, 2024
Accepted: June 19, 2024
Published online: August 26, 2024
Processing time: 71 Days and 18.6 Hours
Core Tip

Core Tip: This research retrospectively harvested clinical data from 86 elderly patients pathologically diagnosed with colorectal cancer to explore the impact of testis-expressed gene 14 (TEX14) and A disintegrin and metalloprotease 17 (ADAM17) expressions on tumor staging, invasion, and metastasis. The outcomes revealed high expressions of TEX14 and ADAM17 in tumor tissues, which were highly correlated with tumor staging, invasion, and metastasis. This suggests that TEX14 and ADAM17 could serve as effective biomarkers for diagnosing and evaluating the progression of CRC in elderly patients.