Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2024; 12(23): 5374-5381
Published online Aug 16, 2024. doi: 10.12998/wjcc.v12.i23.5374
Impact of interleukin 6 levels on acute lung injury risk and disease severity in critically ill sepsis patients
Ya Liu, Li Chen
Ya Liu, Li Chen, Department of Intensive Care Unit, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China
Author contributions: The concept of this study was jointly proposed by Liu Y and Chen L, who participated in the data collection; Liu Y contributed to the formal analysis of this study, and drafted the initial draft; Chen L conducted the research, methodology, and visualization of the manuscript; Liu Y and Chen L participated in this study, validated it, and jointly reviewed and edited the manuscript.
Institutional review board statement: This study has been reviewed and approved by the Ethics Committee of the Ninth Affiliated People's Hospital of Shanghai Jiao Tong University School of Medicine.
Informed consent statement: This study has obtained informed consent forms signed by patients and guardians.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No data available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Chen, MS, Doctor, Department of Intensive Care Unit, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Room 504, Building 14, Baosteel Ba Village Community, Baoshan District, Shanghai 201900, China. wwqh480@163.com
Received: April 24, 2024
Revised: May 16, 2024
Accepted: June 4, 2024
Published online: August 16, 2024
Processing time: 71 Days and 21 Hours
Core Tip

Core Tip: Elevated plasma interleukin-6 (IL-6) levels in septic patients indicate a higher risk of acute lung injury and multiple organ dysfunction syndrome. Monitoring IL-6 levels can help predict disease severity and the development of complications in critically ill patients with sepsis, making it a potential valuable biomarker for early intervention and management strategies.